Agrarian
Bulletin
of the Urals

Russian Journal of Agricultural Research

The publication is registered by the Ministry of the Russian Federation
for Affairs of the Press, Television and Radio Broadcasting and Mass Communication Media.
Registration certificate: PI number 77-12831 on May 31, 2002
Subscription index in catalog «Russian Press» - 16356
ISSN 1997 - 4868 (Print)

The Journal is included in the list of the leading peer-reviewed scientific journals and publications, which should be published by the main results of theses for the degree of doctor and Ph.D.
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Journal is included in the list of VAK (from 25.09.2017), No. 291

ISSN 2307-0005 (Online)
Key title: Agrarnyj vestnik Urala (Online)
Abbreviated key title: Agrar. vestn. Urala (Online)

Аграрный вестник Урала № 04 (158) 2017

Биология и биотехнологии

Забокрицкий Н. А. доктор медицинских наук, старший научный сотрудник, доцент, Институт иммунологии и физиологии Уральского отделения Российской академии наук

Савиных Д. Ю. генеральный директор Научно-производственный центр “Уралбиосинтез”

УДК:[615.331/.372+615.281.9]::636.087.8

EXPERIMENTAL STUDIES OF THE BIOLOGICALLY ACTIVE SUBSTANCE FOR VETERINARY USE

 Thetheoretical researches executed by us, and also long-term experience ofconducting pilot studies of the pro-biotic microorganisms, and practical use ofthe medicines and drugs framed on their basis allowed us to assume apossibility of development of new biologically active substance as a base ofnew perspective drug for a veterinary medicine. For the solution of anobjective it was necessary to conduct first of all researches on the choice ofa pro-biotic microorganism, in pilot studies to study its biological propertiesand based on the received results to make the decision about the expediency ofcreation of an experimental sample of metabolic substance on its basis. Thelargest biological potential and a set of positive properties which caneffectively be used for development of pro-biotic drugs belong to the non-pathogenicsporiferous microorganisms of the sort Bacillusand in particular various strains of a hay rod. It is established that they arecharacterized by the expressed opposing properties concerning many types ofopportunistic and pathogenic microorganisms, ability to have immunomodulatoryeffect (generally due to stimulation of various links of cellular and humoralimmunity), and also have antitoxic, antiallergenic, anti-radiation and othereffects. The experimental sample of biologically active substance is developed onthe basis of metabolites of specially chosen pro-biotic strain of Bacillus subtilis of V-9906 which ischaracterized by the high level of production of such biologically activeagents as albuminous polysaccharide complex, free amino acids, the purine andpyrimidine bases, B2 and B6 vitamins, proteolyticenzymes, antibiotic-like bonds. At experimental modeling of an acutegeneralized salmonellosis, the essential augmentation of survival of laboratoryanimals for whose treatment an experimental sample was used has been discovered.Opposing and biochemical activity, protective and immunotropic properties ofthe developed metabolic substance are studied.


Keywords:

biologically active substance, biochemical and antagonistic activity, protective and immune stimulating properties, the prospect of creating a new drug for veterinary use.


References:

References

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