Аграрный вестник Урала № 11 (178) 2018Биология и биотехнологии
MORPHOLOGICAL PICTURE OF AUTOIMMUNE TYREOIDITIS WITH THE APPEARANCE OF SYSTEMIC IDIOPATHIC FIBROSIS IN HORSE
The articlepresents the materials of the pathologic anatomical dissection and histologicalexamination of the tissues and organs of the domestic horse (Equus feruscaballus), the Friesian breed, as well as materials from the medical history. Anew nosology for this species and breed was first detected in the studiedanimal, namely, a chronic inflammatory disease of the thyroid gland ofautoimmune genesis in the hyperthyroid stage, which caused the development ofsystemic idiopathic fibrosis. The previously detected nosology was notdetected, and also was not described in Russian and foreign literary sources. Thearticle presents materials from the history of the disease with an assessmentof the clinical condition of the animal. A description of the pathological andmorphological changes in the tissues of the thyroid gland with detectedautoimmune thyroiditis, and associated pathological processes in the organs andtissues of the studied animal, as well as a description of the conditionassociated with thyroiditis, namely, systemic idiopathic fibrosis. Along withthis, the peculiarities of the metabolic serum profile of the enzymes,substrates and minerals are presented, the endocrine status of the thyroidgland is assessed by the content of total thyroxin (tT4) and totaltriiodothyronine (tT3), the content of which was 184.0 nmol/l and 7,9 nmol/l,respectively, as well as data indicating the presence of an autoimmune processin relation to thyroid-type antigens, namely, the level of antibodies tothyroglobulin and antibodies to thyroperoxidase, whose content is set 9.7 IU/mland 98 IU/ml, respectively.
thyroid gland, morphology, horses, autoimmune, thyroiditis.
1. Latypov D. G., Zalyalov I. N. Basics of forensic examination. St. Petersburg: Lan, 2015.
2. Vorozhtsova K. S., Potapova O. A. Differential diagnosis of thyroid diseases in horses // Youth and Science. 2017. № 3. P. 6.
3. Vorozhtsova K. S., Potapova E. A., Bespamyatnykh E. N. The introduction of new methods for the differential diagnosis of thyroid diseases in farm animals // Youth and Science. 2017. № 3. P. 7.
4. Zdor V. V., Markelova E. V., Geltser B. I. New participants in the violation of tolerance to antigens of the thyroid gland: the concept of immunopathogenesis of autoimmune diseases of the thyroid gland // Medical Immunology. 2016. V. 18. № 3. P. 209–220.
5. Zubkov A. V., Lunin V. G., Kuzmina N. S. Use of recombinant thyroid autoantigens to identify diagnostically significant epitopes in autoimmune diseases of the thyroid gland / In the collection: International scientific-practical conference “Biotechnology and quality of life” // Proceedings of the conference. 2014. P. 35–36.
6. Botasheva V. S., Khatueva A. A. Dynamics of histological changes in the thyroid gland during experimental thyrotoxicosis // Veterinary Pathology. 2013. № 1 (43). P. 101–103.
7. Skvortsov V. V., Tumarenko A. V. Clinical endocrinology: a short course: study guide / St. Petersburg: SpecLit, 2015. 186 p.
8. Geltser B. I., Zdor V. V., Kotelnikov V. N. The evolution of views on the pathogenesis of autoimmune diseases of the thyroid gland and the prospects for their targeted therapy / Clinical medicine. 2017. V. 95. № 6. P. 524–534.
9. Kalmin O. V., Chairkin I. N., Kalmin O. O. The role of environmental salinity in the development of thyroid pathology // Structural transformations of organs and tissues in normal conditions and under the influence of anthropogenic factors. 2017. P. 81–82.
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