Agrarian
Bulletin
of the Urals

Russian Journal of Agricultural Research

The publication is registered by the Ministry of the Russian Federation
for Affairs of the Press, Television and Radio Broadcasting and Mass Communication Media.
Registration certificate: PI number 77-12831 on May 31, 2002
Subscription index in catalog «Russian Press» - 16356
ISSN 1997 - 4868 (Print)

The Journal is included in the list of the leading peer-reviewed scientific journals and publications, which should be published by the main results of theses for the degree of doctor and Ph.D.
The Journal is included in the Russian Science Citation Index.
Journal is included in the list of VAK (from 25.09.2017), No. 291

ISSN 2307-0005 (Online)
Key title: Agrarnyj vestnik Urala (Online)
Abbreviated key title: Agrar. vestn. Urala (Online)

Аграрный вестник Урала № 11 (178) 2018

Биология и биотехнологии

Дроздова Л. И. доктор ветеринарных наук, профессор, заслуженный деятель науки РФ Уральский государственный аграрный университет

Попова Н. Ю. ветеринарный врач кафедры морфологии, экспертизы и хирургии, Уральский государственный аграрный университет

УДК:631.1:611.44:616.441-002

MORPHOLOGICAL PICTURE OF AUTOIMMUNE TYREOIDITIS WITH THE APPEARANCE OF SYSTEMIC IDIOPATHIC FIBROSIS IN HORSE

The articlepresents the materials of the pathologic anatomical dissection and histologicalexamination of the tissues and organs of the domestic horse (Equus feruscaballus), the Friesian breed, as well as materials from the medical history. Anew nosology for this species and breed was first detected in the studiedanimal, namely, a chronic inflammatory disease of the thyroid gland ofautoimmune genesis in the hyperthyroid stage, which caused the development ofsystemic idiopathic fibrosis. The previously detected nosology was notdetected, and also was not described in Russian and foreign literary sources. Thearticle presents materials from the history of the disease with an assessmentof the clinical condition of the animal. A description of the pathological andmorphological changes in the tissues of the thyroid gland with detectedautoimmune thyroiditis, and associated pathological processes in the organs andtissues of the studied animal, as well as a description of the conditionassociated with thyroiditis, namely, systemic idiopathic fibrosis. Along withthis, the peculiarities of the metabolic serum profile of the enzymes,substrates and minerals are presented, the endocrine status of the thyroidgland is assessed by the content of total thyroxin (tT4) and totaltriiodothyronine (tT3), the content of which was 184.0 nmol/l and 7,9 nmol/l,respectively, as well as data indicating the presence of an autoimmune processin relation to thyroid-type antigens, namely, the level of antibodies tothyroglobulin and antibodies to thyroperoxidase, whose content is set 9.7 IU/mland 98 IU/ml, respectively.


Keywords:

thyroid gland, morphology, horses, autoimmune, thyroiditis.


References:

1. Latypov D. G., Zalyalov I. N. Basics of forensic examination. St. Petersburg: Lan, 2015.

2. Vorozhtsova K. S., Potapova O. A. Differential diagnosis of thyroid diseases in horses // Youth and Science. 2017. № 3. P. 6.

3. Vorozhtsova K. S., Potapova E. A., Bespamyatnykh E. N. The introduction of new methods for the differential diagnosis of thyroid diseases in farm animals // Youth and Science. 2017. № 3. P. 7.

4. Zdor V. V., Markelova E. V., Geltser B. I. New participants in the violation of tolerance to antigens of the thyroid gland: the concept of immunopathogenesis of autoimmune diseases of the thyroid gland // Medical Immunology. 2016. V. 18. № 3. P. 209–220.

5. Zubkov A. V., Lunin V. G., Kuzmina N. S. Use of recombinant thyroid autoantigens to identify diagnostically significant epitopes in autoimmune diseases of the thyroid gland / In the collection: International scientific-practical conference “Biotechnology and quality of life” // Proceedings of the conference. 2014. P. 35–36.

6. Botasheva V. S., Khatueva A. A. Dynamics of histological changes in the thyroid gland during experimental thyrotoxicosis // Veterinary Pathology. 2013. № 1 (43). P. 101–103.

7. Skvortsov V. V., Tumarenko A. V. Clinical endocrinology: a short course: study guide / St. Petersburg: SpecLit, 2015. 186 p.

8. Geltser B. I., Zdor V. V., Kotelnikov V. N. The evolution of views on the pathogenesis of autoimmune diseases of the thyroid gland and the prospects for their targeted therapy / Clinical medicine. 2017. V. 95. № 6. P. 524–534.

9. Kalmin O. V., Chairkin I. N., Kalmin O. O. The role of environmental salinity in the development of thyroid pathology // Structural transformations of organs and tissues in normal conditions and under the influence of anthropogenic factors. 2017. P. 81–82.


Download article as PDF:

8.pdf (414 KB)

Our database contains 2917 authors

We have published 2740 articles in 133 issues.

Bg