Agrarian
Bulletin
of the Urals

Russian Journal of Agricultural Research

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Registration certificate: PI number 77-12831 on May 31, 2002
Subscription index in catalog «Russian Press» - 16356
ISSN 1997 - 4868 (Print)

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Journal is included in the list of VAK (from 25.09.2017), No. 291

ISSN 2307-0005 (Online)
Key title: Agrarnyj vestnik Urala (Online)
Abbreviated key title: Agrar. vestn. Urala (Online)

Аграрный вестник Урала № 04 (83) 2011

Ветеринария

Татарникова Н. А. доктор ветеринарных наук, профессор, заведующий кафедрой Пермская государственная сельскохозяйственная академия

Самоделкин Е. И. Доктор медицинских наук

Кульневская М. Н. Кандидат ветеринарных наук, заведующий кафедрой

Неклюдова В. В. Соискатель

Черанева М. В. Соискатель, Пермская ГСХА им. акад. Д. Н. Прянишникова

Косарева П. В. Доктор медицинских наук, заведующий отделом морфологических и патофизиологических исследований ЦНИЛ ПГМА

Никитин С. В. Соискатель, Пермская ГМА им. акад. Е. А. Вагнера

УДК:615.276.051.4.06

FARMACOLOGIC REGULATION OF ACIDIC-PEPTIC FACTOR ACTIVITY IN LONG-TERM THERAPY WITH NON-STEROID ANTI-INFLAMMATORY PREPARATIONS.

We tested new methods of treatment and
prevention of non-steroid anti-inflammatory
preparation — gastropathy experimental
therapy on the basis of elaborated original
model of non-steroid anti-inflammatory
preparation — gastropathy in experimental
animals receiving non-steroid antiinflammatory
preparations Ketofen® and
“Nise®” in combination with 5 % solution
of ascorbic acid orally. The animals of the
experimental group were given Omez® to
regulate acidic-peptic factor of the stomach.
Dystrophic changes of the stomach mucous
membrane epitheliocytes were noted in
40 % of cases in animals receiving Ketofen®
and in 20 % of animals receiving Nise®. In
some preparations (70 %) there was some
thickening of mucous membrane plasty
caused by tissue edema and hypertrophy
of stomach mucous membrane muscular
plasty. In animals receiving Famotidin®
dystrophy was noted in 33,3% (Ketofen®)
and 26,7 % (Nise®) of cases. Thickening
of mucous membrane plasty and mucous
membrane muscular plasty was noted in
46,67 % of animals with non-steroid antiinflammatory
preparation — gastropathy
caused by Nise® preparation and in
20 % of animals receiving Famotidin®. 


Keywords:

experimental non-steroid anti-inflammatory preparation – gastropathy, “Nise®”, Ketofen®, Omez®, Famotidin®, histology, regulatory protein Ki – 67 expression, morphometric analysis, immunohistochemical studies.


References:


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